SANS Thermal Place Preference for Mice and Rats

The Thermal Place Preference Test (TPPT) is an advanced behavioral assay designed to evaluate thermal sensitivity and temperature-driven behavior in rodents. As described in Moqrich et al. (Science, 2005), TPPT is a significant evolution of the traditional hot plate and hot-cold plate tests. It enables researchers to finely quantify thermal hyperalgesia and cold allodynia in models of neuropathic pain, such as chronic constriction injury (CCI).

TPPT allows rats or mice to freely choose between two emperature-controlled plates, offering insights into their pain threshold, nociceptive responses, and inflammation-driven behavior.

As advised by A. MOQRICH, and published in Moqrich et al (Science 2005, 307: 1468-72), the thermal place preference test (TPPT) was designed to finely assess thermal sensitivity in rodents. It can detect, quantify, and differentiate behavioral responses to cold stimuli between sham and chronic constriction injury (CCI) rodents.

The Thermal Place Preference Test, also call as 2 Temperatures Choice Nociception Test, based on two Hot Cold Plate (Temperature range from -5°C to 65 °C)，allows researchers to work on free moving animals (Rats and Mice) to choose their preferred place between 2 compartments set a different temperature. Our Thermal Place Preference adopts dynamic infrared scanning tracking technology to record the location of the rodents and automatically analyze the staying time and times in each compartment. TPPT enables a fine-grained assessment of thermal sensitivity that is relevant to the pathophysiological exploration of animal pain models and to the pharmacological assessment of analgesic drugs.