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Description
RS-SI is an automated and intelligent stereotaxic instrument with high precision (1 μm). The software has built-in rat and mouse brain atlas and automatic procedures (skull window, tissue removal and automated injection procedure), which can be observing the position of the probe relative to the brain area is convenient and efficient, and the operation is easy to use, greatly reducing the errors and damage caused by manual operation. In addition, it has an anti-collision function to prevent animal damage caused by wrong movement, which is safer.
The mouse head can be easily rotated flexibility so as to adjust the level of the skull. The accuracy of mediolateral rotation perfectly solves the bleeding problem when you inject through the venous sinus. Alignment Indicator can feedback whether the height of the animal’s head is horizontal. Centering Scope helps find Bregma and Lambda points. And you don’t need to set up Bregma repeatedly.
Key Benefits
★ Precision
1micron resolution.
Motor instead of manual, precise control of displacement.
★ Precise Positioning Without Leveling
Atlas Calibration Function, accurate positioning without leveling.
★ Atlas Integration
Visualization of probe displacement.
★ Tiltable Injection
Manipulators Tilt Function, no need to manually calculate the positioning path.
★ Automated Functions
Automated procedures such as Skull Window, Tissue Removal, and Automated Injection programs are more efficient and convenient.
★ High Repeatability
User Cases
some cases:
-Institute of Neuroscience of Soochow University:
The accuracy of the Automated Stereotaxic Instrument is 1um, which greatly improves the repeatability of the experiment and saves a lot of manual operation time.
-Nanfang Hospital:
The operation is simple and easy to use, the Skull Window program does not need to hold a cranial drill, which avoids the damage caused by manual operation.
Reference
1. Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H. blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 2018 Feb 14;554(7692):317-322.
2. Cui Y, Yang Y, Ni Z, Dong Y, Cai G, Foncelle A, Ma S, Sang K, Tang S, Li Y, Shen Y, Berry H, Wu S, Hu H. Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature. 2018 Feb 14;554(7692):323-327.
3. Zhou H, Xiong GJ, Jing L, Song NN, Pu DL, Tang X, He XB, Xu FQ, Huang JF, Li LJ, Richter-Levin G, Mao RR, Zhou QX, Ding YQ, Xu L. The interhemispheric CA1 circuit governs rapid generalisation but not fear memory. Nat Commun. 2017 Dec 19;8(1):2190.
4. Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q, Zhao Z, Zheng J, Han Y, Xu F, Luo M, Sollars PJ, Pu M, Pickard GE, So KF, Ren C. A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour. Nat Commun. 2017 Mar 31;8:14908.
5. Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, Zhang Y, Pei F, Li S, Yi M, Shu Y, Shang Y, Liang J, Huang Z. CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. Nat Commun. 2017 Aug 25;8(1):355.
6. Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP, Wang Y. Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015 Jul 16;6:7660.
7. Li WG, Liu MG, Deng S, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F, Zhu MX, Xu TL. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun. 2016 Dec 7;7:13770.
8. Hao X, Gu H, Chen C, Huang D, Zhao Y, Xie L, Zou Y, Shu HS, Zhang Y, He X, Lai X, Zhang X, Zhou BO, Zhang CC, Chen GQ, Yu Z, Yang Y, Zheng J. Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche. Cell Metab. 2019 Apr 2;29(4):950-965.
9. Diao Y, Cui L, Chen Y, Burbridge TJ, Han W, Wirth B, Sestan N, Crair MC, Zhang J. Reciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus. Cereb Cortex. 2018 Apr 1;28(4):1168-1182.
10. Chen X, Guo Y, Feng J, Liao Z, Li X, Wang H, Li X, He J. Encoding and retrieval of artificial visuoauditory memory traces in the auditory cortex requires the entorhinal cortex. J Neurosci. 2013 Jun 12;33(24):9963-74.
Specification
| Working environment |
Temperature:5°C~40°C Humidity: 15%~95% Air pressure: 57kPa~106kPa |
| Storage environment |
Temperature:-20°C~60°C Humidity: 10%~9% Air pressure: 50 kPa ~ 106 kPa |
| Power supply |
AC power: 90 V~264 V,50/60Hz DC power: 24 VDC,1.5 A,36 W The voltage fluctuation does not exceed 1% of the working voltage range. |
Order Information
| Category | Model | Product Description | Remark |
| Stereotaxic host (without accessories) | RS-SI | Automated Stereotaxic Instrument, SGL.M, Automatic Injection | Left manipulator and nanoliter injection pump included, without adaptor, ear bars, holder and mask |
| RS-S | Automated Stereotaxic Instrument, SGL.M | Left manipulator, without adaptor, ear bars, holder and mask | |
| RS-DI | Automated Stereotaxic Instrument, Dual.M, Automatic Injection | Two manipulators and nanoliter injection pump included, without adaptor, ear bars, holder and mask | |
| RS-D | Automated Stereotaxic Instrument, Dual.M | Two manipulators, without adaptor, ear bars, holder and mask | |
| Required accessories (optional)* | 68055 | Mouse Adaptor | |
| 68030 | Mouse/Neonatal Rat Adaptor | ||
| 68057 | Mouse Anesthesia Adaptor | ||
| 68021 | Rat Adaptor | ||
| 68053 | Rat Anesthesia Adaptor | ||
| 68301 | Rat 18° Ear Bars | ||
| 68306 | Mouse 60° Ear Bars | ||
| 68201 | Standard Probe Holder-Corner | ||
| TRA-220 | Tissue Removal Optional Kit (220V ) | Optional when using tissue removal procedure, including needle connector, holder (68202), vacuum pump-GM-0.5Ⅱ -220V-50HZ, liquid storage tank, connecting tube, needle. | |
| TRA-110 | Tissue Removal Optional Kit (110V ) | Optional when using tissue removal procedure, including needle connector, holder (68202), vacuum pump-GM-0.5Ⅱ -110V-50HZ, liquid storage tank, connecting tube, needle. | |
| 71000-LT | Laptop for Automated Stereotaxic Instrument (software included) | i3-1215U/8G/256G/WIN10/Set display/14″ |
*Indicates that other specifications can be selected, which can be viewed from the product catalog of RWD.
RS-SI Automated Stereotaxic Instrument
$15,500.00
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